InP Nanowire Biosensor with Tailored Biofunctionalization: Ultrasensitive and Highly Selective Disease Biomarker Detection

Highly sensitive covalently functionalised integrated silicon nanowire biosensor devices for detection of cancer risk biomarker.

In this article we present ultra-sensitive, silicon nanowire (SiNW)-based biosensor devices for the detection of disease biomarkers. An electrochemically induced functionalisation method has been employed to graft antibodies targeted against the prostate cancer risk biomarker 8-hydroxydeoxyguanosine (8-OHdG) to SiNW surfaces. The antibody-functionalised SiNW sensor has been used to detect bindi...

Ultrasensitive and highly selective detection of Alzheimer's disease biomarker using two-photon Rayleigh scattering properties of gold nanoparticle.

Alzheimer's disease (AD) is a progressive mental disorder disease, which affects 26.6 million people worldwide and estimated increments can be 100 millions by 2050. Since there is no cure at present, early diagnosis of AD is crucial for the current drug treatments. Driven by the need, here we demonstrate for the first time that monoclonal anti-tau antibody-coated gold nanoparticle based two-pho...

A novel electrochemical biosensor for highly selective detection of protease biomarker from Bacillus licheniformis with D-amino acid containing peptide.

A simple, selective and sensitive electrochemical biosensor has been developed to detect protease biomarker from Bacillus licheniformis, a recognized model of the biochemical warfare agent Bacillus anthracis. In this assay, the biosensor is constructed using a d-amine acid containing substrate peptide via self-assembly of cysteine residual at the C-terminal. A biotin modifier is labelled at the...

Ultrasensitive and Selective Multiplexing Detection of Cancer Markers Using Nanowire Nanosensors

Nanoscience enables ultrasensitive detection of Alzheimer's biomarker.

A lzheimer’s disease (AD), which afflicts an estimated 16 million people worldwide, is a neurodegenerative dementia characterized by memory loss and cognitive impairment (1). Symptoms begin with mild cognitive impairment that cannot be distinguished from other more benign forms of age-related dementia. Even as the disease progresses, clinical diagnosis can be made with only 65– 90% accuracy. AD...